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chiharu moriya


Chiharu Moriya: A Japanese Scientist Working on RNAi Therapy for Cancer

Chiharu Moriya: A Japanese Scientist Working on RNAi Therapy for Cancer

Chiharu Moriya is a researcher at the Center for Antibody and Vaccine Therapy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Japan . She is involved in developing an innovative RNA interference (RNAi) therapy for cancer, especially pancreatic cancer.

RNAi is a natural process that silences the expression of specific genes by using small molecules of RNA called siRNAs. By designing siRNAs that target cancer-related genes, RNAi therapy can potentially stop the growth and spread of tumors.

One of the challenges of RNAi therapy is delivering the siRNAs to the tumor cells without being degraded by enzymes or cleared by the immune system. Moriya and her colleagues have overcome this challenge by using a novel nanocarrier system that protects and transports the siRNAs to the tumor site .

The nanocarrier system consists of a polymeric micelle, which is a spherical structure made of biodegradable polymers, and a pH-sensitive fusogenic peptide, which is a short protein that can fuse with cell membranes. The siRNAs are encapsulated inside the micelle and released into the tumor cells when the peptide interacts with the acidic environment of the tumor .

Moriya and her colleagues have focused on silencing a gene called PRDM14, which is overexpressed in pancreatic cancer and contributes to its aggressiveness and resistance to chemotherapy. They have shown that their nanocarrier system can efficiently deliver siRNAs against PRDM14 to pancreatic cancer cells in vitro and in vivo, and suppress their growth and metastasis .

Their research has demonstrated the feasibility and efficacy of RNAi therapy for pancreatic cancer, which is one of the most lethal and difficult-to-treat cancers. They hope that their nanocarrier system can be applied to other types of cancer and other diseases that can be treated by gene silencing .

Chiharu Moriya is a promising young scientist who is making significant contributions to the field of RNAi therapy. She has published several papers in prestigious journals and received awards for her work. She is also a member of various academic societies and organizations related to cancer research .

In addition to her research on RNAi therapy, Moriya is also interested in exploring the molecular mechanisms and functions of PRDM14 in cancer and other diseases. PRDM14 is a transcription factor that regulates the expression of genes involved in pluripotency, differentiation, and reprogramming of cells .

PRDM14 is normally expressed in embryonic stem cells and germ cells, but it is aberrantly expressed in various cancers, such as pancreatic, breast, ovarian, and testicular cancers. Moriya and her colleagues have found that PRDM14 promotes the stemness and invasiveness of cancer cells by activating a network of genes related to epithelial-mesenchymal transition (EMT), a process that allows cancer cells to detach from their original tissue and migrate to other organs .

By silencing PRDM14 expression, Moriya and her colleagues have shown that they can reverse the EMT process and reduce the stemness and metastatic potential of cancer cells. They have also discovered that PRDM14 interacts with other transcription factors and epigenetic modifiers to regulate the chromatin structure and gene expression of cancer cells .

Moriya’s work on PRDM14 has revealed new insights into the molecular basis of cancer development and progression. She has also identified PRDM14 as a potential biomarker and therapeutic target for cancer diagnosis and treatment .


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